Herman C (2006) What makes a screening exam “good”? AMA J Ethics 8:34–37. Obuchowski NA, Graham RJ, Baker ME, Powell KA (2001) Ten criteria for effective screening: their application to multislice CT screening for pulmonary and colorectal cancers. īull MJ, American Academy of Pediatrics, the Committee on Genetics (2011) Health supervision for children with Down syndrome. Roizen NJ, Patterson D (2003) Down’s syndrome. O’Brien WT, Shen P, Lee P (2015) The dens: normal development, developmental variants and anomalies, and traumatic injuries. Pang D, Thompson DNP (2011) Embryology and bony malformations of the craniovertebral junction. Tomlinson C, Campbell A, Hurley A, Fenton E, Heron N (2018) Sport preparticipation screening for asymptomatic atlantoaxial instability in patients with Down syndrome. īertolizio G, Saint-Martin C, Ingelmo P (2018) Cervical instability in patients with Trisomy 21: the eternal gamble. This experience supports the appositeness of the de-escalation of care asserted by the guidelines.Īli FE, Al-Bustan MA, Al-Busairi WA et al (2006) Cervical spine abnormalities associated with Down syndrome. Routine radiographic screening may not be sufficiently predictive of DS individuals at risk to develop AAI. She was diagnosed and treated for atlantoaxial subluxation associated with os odontoideum. Our exemplary patient presented to the emergency department for neck pain without a history of significant trauma. The clinical experience of the Sie Center demonstrates that even when limiting imaging to patients who show signs or symptoms of spine pathology, the vast majority of x-rays are negative. We also report an illustrative case of a 5-year-old female with Down syndrome who presented with instability after normal screening radiographs per the pre-2011 guidelines. We reviewed the courses of patients with DS seen at the Sie Center for Down Syndrome at Children’s Hospital Colorado who were evaluated for cervical spine disease and determined whether screening radiographic imaging could have led to earlier diagnosis or prevented development of neurological deficits. We provide the first neurosurgical review of a large experience implementing the 2011 AAP guidelines. An assessment of whether this alteration has been associated with an increase in AAI-associated spinal cord injury has not been undertaken. In 2011, the American Academy of Pediatrics (AAP) updated its AAI screening guidelines for children with DS from radiographic screening to radiographs only if there are clinical symptoms suggestive of cervical spine pathology. ![]() ![]() Atlantoaxial instability (AAI) has a higher incidence rate among individuals with Down syndrome (DS) than the non-DS population.
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